GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9309473 | 1 | rs7558944 | chr2:73810909 | ALMS1P | chr2:73872046-73912692:+ | 0.49 | 5.73 | 5.35E-8 | Metabolite levels |
| UCEC | cis | rs7563911 | 1 | rs7563911 | chr2:201576284 | PPIL3 | chr2:201735680-201753999:- | 0.45 | 4.46 | 1.56E-5 | Intelligence |
| UCEC | cis | rs9309473 | 1 | rs7564890 | chr2:73641853 | ALMS1P | chr2:73872046-73912692:+ | 0.46 | 5.33 | 3.44E-7 | Metabolite levels |
| UCEC | cis | rs60843830 | 1 | rs7566279 | chr2:281178 | SH3YL1 | chr2:218138-264810:- | -0.5 | -6.71 | 3.65E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9309473 | 1 | rs7572722 | chr2:73724675 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.52 | 1.45E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs7576245 | chr2:73829678 | ALMS1P | chr2:73872046-73912692:+ | 0.53 | 6.21 | 4.72E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs7580825 | chr2:73635148 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 5.93 | 1.92E-8 | Metabolite levels |
| UCEC | cis | rs7581224 | 1 | rs7581224 | chr2:84709215 | DNAH6 | chr2:84743579-85046711:+ | 0.25 | 5 | 1.56E-6 | Coronary artery calcification |
| UCEC | cis | rs9309473 | 1 | rs7582606 | chr2:73813945 | ALMS1P | chr2:73872046-73912692:+ | 0.49 | 5.73 | 5.35E-8 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs7583255 | chr2:73797996 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.52 | 1.45E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs7584575 | chr2:73666402 | ALMS1P | chr2:73872046-73912692:+ | 0.53 | 6.24 | 4.25E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs7585004 | chr2:73666645 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 5.97 | 1.64E-8 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs7586463 | chr2:73798476 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.52 | 1.45E-7 | Metabolite levels |
| UCEC | cis | rs12220777 | 1 | rs75913297 | chr10:81789845 | LOC219347 | chr10:81805991-81838949:- | 0.71 | 5.1 | 9.92E-7 | Chronic obstructive pulmonary disease-related biomarkers |
| UCEC | cis | rs7591472 | 1 | rs7591472 | chr2:201889751 | PPIL3 | chr2:201735680-201753999:- | -0.69 | -6.78 | 2.45E-10 | Triptolide cytotoxicity |